766 research outputs found
The effect of abstract versus concrete framing on judgments of biological and psychological bases of behavior
Human behavior is frequently described both in abstract, general terms and in concrete, specific terms. We asked whether these two ways of framing equivalent behaviors shift the inferences people make about the biological and psychological bases of those behaviors. In five experiments, we manipulated whether behaviors are presented concretely (i.e. with reference to a specific person, instantiated in the particular context of that person’s life) or abstractly (i.e. with reference to a category of people or behaviors across generalized contexts). People judged concretely framed behaviors to be less biologically based and, on some dimensions, more psychologically based than the same behaviors framed in the abstract. These findings held true for both mental disorders (Experiments 1 and 2) and everyday behaviors (Experiments 4 and 5) and yielded downstream consequences for the perceived efficacy of disorder treatments (Experiment 3). Implications for science educators, students of science, and members of the lay public are discussed
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Ribosome Biogenesis Modulates Ty1 Copy Number Control in Saccharomyces cerevisiae.
Transposons can impact the host genome by altering gene expression and participating in chromosome rearrangements. Therefore, organisms evolved different ways to minimize the level of transposition. In Saccharomyces cerevisiae and its close relative S. paradoxus, Ty1 copy number control (CNC) is mediated by the self-encoded restriction factor p22, which is derived from the GAG capsid gene and inhibits virus-like particle (VLP) assembly and function. Based on secondary screens of Ty1 cofactors, we identified LOC1, a RNA localization/ribosome biogenesis gene that affects Ty1 mobility predominantly in strains harboring Ty1 elements. Ribosomal protein mutants rps0bΔ and rpl7aΔ displayed similar CNC-specific phenotypes as loc1Δ, suggesting that ribosome biogenesis is critical for CNC. The level of Ty1 mRNA and Ty1 internal (Ty1i) transcripts encoding p22 was altered in these mutants, and displayed a trend where the level of Ty1i RNA increased relative to full-length Ty1 mRNA. The level of p22 increased in these mutants, and the half-life of p22 also increased in a loc1Δ mutant. Transcriptomic analyses revealed small changes in the level of Ty1 transcripts or efficiency of translation initiation in a loc1Δ mutant. Importantly, a loc1Δ mutant had defects in assembly of Gag complexes and packaging Ty1 RNA. Our results indicate that defective ribosome biogenesis enhances CNC by increasing the level of p22, and raise the possibility for versatile links between VLP assembly, its cytoplasmic environment, and a novel stress response
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Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer
BACKGROUND:
A behavioral phenotype that characterizes nicotine dependence, the time to first cigarette after waking, is hypothesized to increase the risk of head and neck cancer.
METHODS:
A case-control study of histologically confirmed head and neck cancer was conducted that included 1055 cases and 795 controls with a history of cigarette smoking.
RESULTS:
The pack-years–adjusted odds ratio was 1.42 (95% confidence interval [95% CI], 1.02-1.99) for an interval of 31 minutes to 60 minutes to first cigarette after waking and 1.59 (95% CI, 1.19-2.11) for an interval of 1 minute to 30 minutes. The risk estimates were similar when smoking was modeled as total years, smoking status (current vs former), number of cigarettes smoked per day, years since quitting, and excess odds ratio. Findings were consistent for cancers of the floor of the mouth, palate, and pharynx.
CONCLUSIONS:
Time to first cigarette is an indicator of increased nicotine dependence, smoke uptake, and risk of head and neck cancer. This high-risk group of individuals would benefit from targeted smoking interventions
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Nicotine dependence phenotype and lung cancer risk
BACKGROUND:
A behavioral phenotype that characterizes nicotine dependence, the time to first cigarette after waking, is hypothesized to increase the risk of lung cancer.
METHODS:
A case-control study of histologically confirmed lung cancer was conducted. The current analysis included 4775 lung cancer cases and 2835 controls who were regular cigarette smokers.
RESULTS:
Compared with subjects who smoked their first cigarette > 60 minutes after waking, the pack-years–adjusted odds ratio was 1.31 (95% confidence interval [95% CI], 1.11-1.54) for subjects who smoked 31 minutes to 60 minutes after waking and 1.79 (95% CI, 1.56-2.07) for subjects who smoked within 30 minutes of waking. The risk estimates were similar when smoking was modeled as total years, smoking status (current vs former), number of cigarettes smoked per day, years since quitting, and excess odds ratio. The findings were consistent for all histologic types of lung cancer.
CONCLUSIONS:
The findings of the current study indicate that a specific nicotine dependence phenotype that is associated with the amount of smoke uptake per cigarette is independently associated with lung cancer risk. These findings may help to identify high-risk individuals who would benefit from targeted interventions
B2 0902+34: A Collapsing Protogiant Elliptical Galaxy at z=3.4
We have used the visible integral-field replicable unit spectrograph
prototype (VIRUS-P), a new integral field spectrograph, to study the spatially
and spectrally resolved Lyman-alpha emission line structure in the radio galaxy
B2 0902+34 at z=3.4. We observe a halo of Lyman-alpha emission with a velocity
dispersion of 250 km/s extending to a radius of 50 kpc. A second feature is
revealed in a spatially resolved region where the line profile shows
blueshifted structure. This may be viewed as either HI absorption at -450 km/s
or secondary emission at -900 km/s from the primary peak. Our new data, in
combination with the 21 cm absorption, suggest two important and unexplained
discrepancies. First, nowhere in the line profiles of the Lyman-alpha halo is
the 21 cm absorber population evident. Second, the 21 cm absorption redshift is
higher than the Lyman-alpha emission redshift. In an effort to explain these
two traits, we have undertaken the first three dimensional Monte Carlo
simulations of resonant scattering in radio galaxies. Though simple, the model
produces the features in the Lyman-alpha data and predicts the 21 cm
properties. To reach agreement between this model and the data, global infall
of the HI is strictly necessary. The amount of gas necessary to match the model
and data is surprisingly high, >= 10E12 solar masses, an order of magnitude
larger than the stellar mass. The collapsing structure and large gas mass lead
us to interpret B2 0902+34 as a protogiant elliptical galaxy.Comment: 30 pages, 8 figures, 4 tables, accepted in Ap
How inter-rater variability relates to aleatoric and epistemic uncertainty: a case study with deep learning-based paraspinal muscle segmentation
Recent developments in deep learning (DL) techniques have led to great
performance improvement in medical image segmentation tasks, especially with
the latest Transformer model and its variants. While labels from fusing
multi-rater manual segmentations are often employed as ideal ground truths in
DL model training, inter-rater variability due to factors such as training
bias, image noise, and extreme anatomical variability can still affect the
performance and uncertainty of the resulting algorithms. Knowledge regarding
how inter-rater variability affects the reliability of the resulting DL
algorithms, a key element in clinical deployment, can help inform better
training data construction and DL models, but has not been explored
extensively. In this paper, we measure aleatoric and epistemic uncertainties
using test-time augmentation (TTA), test-time dropout (TTD), and deep ensemble
to explore their relationship with inter-rater variability. Furthermore, we
compare UNet and TransUNet to study the impacts of Transformers on model
uncertainty with two label fusion strategies. We conduct a case study using
multi-class paraspinal muscle segmentation from T2w MRIs. Our study reveals the
interplay between inter-rater variability and uncertainties, affected by
choices of label fusion strategies and DL models.Comment: Accepted in UNSURE MICCAI 202
Matrix Models, Monopoles and Modified Moduli
Motivated by the Dijkgraaf-Vafa correspondence, we consider the matrix model
duals of N=1 supersymmetric SU(Nc) gauge theories with Nf flavors. We
demonstrate via the matrix model solutions a relation between vacua of theories
with different numbers of colors and flavors. This relation is due to an N=2
nonrenormalization theorem which is inherited by these N=1 theories.
Specializing to the case Nf=Nc, the simplest theory containing baryons, we
demonstrate that the explicit matrix model predictions for the locations on the
Coulomb branch at which monopoles condense are consistent with the quantum
modified constraints on the moduli in the theory. The matrix model solutions
include the case that baryons obtain vacuum expectation values. In specific
cases we check explicitly that these results are also consistent with the
factorization of corresponding Seiberg-Witten curves. Certain results are
easily understood in terms of M5-brane constructions of these gauge theories.Comment: 27 pages, LaTeX, 2 figure
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase
Integrating biological information from different sources to understand
cellular processes is an important problem in systems biology. We use data from
mRNA expression arrays and chemical kinetics to formulate a metabolic model
relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters
the expression of metabolic enzymes in K562 cells. Our array data show changes
in expression of lactate dehydrogenase (LDH) isoforms after treatment with
phorbol 12-myristate 13-acetate (PMA), which activates MAP kinase signaling. We
model the change in lactate production which occurs when the MAP kinase pathway
is activated, using a non-equilibrium, chemical-kinetic model of homolactic
fermentation. In particular, we examine the role of LDH isoforms, which
catalyze the conversion of pyruvate to lactate. Changes in the isoform ratio
are not the primary determinant of the production of lactate. Rather, the total
concentration of LDH controls the lactate concentration.Comment: In press, Journal of Theoretical Biology. 27 pages, 9 figure
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